The Pathomorphology Department has co-operated for many years with the Oncological Surgery Clinic for Children and Adolescents at the IMC. Our plans and scientific endeavours also focus on children's oncology. We conduct in-depth studies on the morphology of solid tumours in children and adolescents, with special emphasis on musculo-skeletal cancer (tumours of periosteal soft tissues and bones). These studies are focused on searching for morphological prognostic markers, with particular emphasis of preoperative chemotherapy used in the treatment of these tumours, with the application of immunohistochemical diagnostic methods and molecular tests.
The Molecular Oncology Laboratory, which has been part of the Department since late 2001, began molecular tests in solid tumours in children, with particular emphasis on chromosomal abnormalities occurring in those tumours. The Laboratory also studies the expression of tumour suppressor genes and oncogenes involved in the formation and development of tumours.
Within its scientific activity, the Department has participated in research projects conducted in collaboration with the IMC Obstetrics and Gynaecology Clinic. The topics in focus included occurrence of infections of the lower genital tract in women in correlation with the occurrence of preterm labour as well as clinical and morphological problems connected with labour from complicated pregnancy with preeclampsia.
In our research projects related to childhood cancers, we deal with important life processes in cancer cells (proliferation, apoptosis, angiogenesis, drug resistance), in small round cell tumours of soft periosteal tissues and bones, as well as osteosarcomas, running an analysis at the level of immunohistochemical tests as well as molecular tests. The combination of both diagnostic methods takes place in our ongoing research projects conducted in collaboration with the Paediatric Surgical Oncology Clinic at the IMC.
For many years, the Pathomorphology Department has provided consultations for the Polish Paediatric Group for the Treatment of Solid Tumours in Children in areas such as neuroblastoma, nephroblastoma, bone tumours and solid tumours of soft periosteal tissues.
In 2007, as a result of many years of collaboration, the competitions committee awarded a task to the Department under the National Programme for Against Cancer.
In total, in the last two years, the Department's staff members took part in work on two topics under the so-called ordered projects financed by the Committee for Scientific Research, four research projects and two doctoral grant projects. The Department has also prepared expert opinions for the Polish Ministry of Health.
Apart from the aforementioned research and development activities, our Department also offers services for the IMC inpatient and outpatient clinics (based on its statutes) as well as commercial activities.
For five years now, the Pathomorphology Department has participated in the Cervical Cancer Prevention Programme under a contract with the National Health Fund (NFZ).
Molecular Oncology Laboratory
dr n. med. Teresa Klepacka
22 32 77 259
Main Building, 3rd floor